Uremic Solutes Database
Solute Details for Indoxyl sulfate (free)
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Base data
Name Indoxyl sulfate (free)
Molecular weight 212
Group Indole
Class Protein-bound [4]
Added 01.08.2012
Reference Pubmed: 22626821
Submitted by Duranton
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
12.11.20060.53 (+/-0.29) mg/L15Hemodialysis reduces inhibitory effec...Abou DeifArgiles[2]
Grand mean0.53 (+/-0.29) mg/L15

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
03.12.20033.60 (+/-2.70) mg/L10Studies on dialysate mixing in the Ge...Abou DeifArgiles
05.11.20063.69 (+/-2.40) mg/L111The importance of residual renal func...Abou DeifArgiles
12.11.20062.09 (+/-2.25) mg/L10Hemodialysis reduces inhibitory effec...Abou DeifArgiles[2]
07.02.20072.70 (+/-1.30) mg/L11Effect of the super-flux cellulose tr...Abou DeifArgiles
07.02.20114.49 (+/-2.67) mg/L71Factors associated with blood concent...Abou DeifArgiles
Grand mean3.83 (+/-2.46) (2.09-4.49) mg/L213
ANOVAF(4,208) = 6.28, p=0.00: Significant differences between group means.
DispersionL:2.09, M:3.83, H:4.49 : A - (Minimal scatter: High consistency.)

Relative increase (CU/CN) 7.19 times higher than the average normal concentration.

Pathological associations
04.05.2012NephrologicUremic toxins induce kidney fibrosis ...Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition.
02.11.2012Nephrologicp-Cresyl sulphate and indoxyl sulphat...Indoxyl sulfate levels may help in predicting the risk of renal progression in patients having different stages of CKD.

2Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]
4This protein-bound solute has a molecular weight conforming to middle molecules.