Uremic Solutes Database
Solute Details for Phenylacetic acid
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Base data
Name Phenylacetic acid
Molecular weight 136
Group other
Class Protein-bound [4]
Added 01.08.2012
Reference Pubmed: 22626821
Submitted by Duranton
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
07.04.20041.40 mg/L1Increased plasma phenylacetic acid in...Abou DeifArgiles[10] [16]
Grand mean1.40 mg/L1

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
07.04.2004474.64 (+/-44.88) mg/L41Increased plasma phenylacetic acid in...Abou DeifArgiles[2]
Grand mean474.64 (+/-44.88) mg/L41

Relative increase (CU/CN) 339.03 times higher than the average normal concentration.

Pathological associations
07.04.2004CardiovascularIncreased plasma phenylacetic acid in...Accumulation of phenylacetic acid in patients with end-stage renal failure [...] may contribute to increased atherosclerosis and cardiovascular morbidity.
10.04.2009ImmunologicThe uraemic toxin phenylacetic acid i...iNOS inhibition by PAA might affect immunoregulatory processes and could play a role in aggravation of immunodeficiency of patients with end-stage renal disease.

2Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]
4This protein-bound solute has a molecular weight conforming to middle molecules.
10Only maximum range available, or detection limit used as maximum range.
16Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.