Uremic Solutes Database
Solute Details for Hyaluronic acid (Hyaluronan)
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Base data
Name Hyaluronic acid (Hyaluronan)
Molecular weight 25000
Group Peptide
Class Middle molecule
Added 16.09.2009
Reference Pubmed: 12675874
Submitted by Vanholder
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
29.10.1999 (?-124.00) µg/L86Factors that influence serum hyaluron...VanholderAbou Deif[10] [16]
Grand mean124.00 µg/L86

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
23.07.1996216.50 (17.00-1174.00) µg/L38Serum hyaluronan concentrations predi...Abou DeifArgiles[16]
29.10.1999215.00 (+/-257.00) (32.00-1843.00) µg/L184Factors that influence serum hyaluron...VanholderAbou Deif
Grand mean215.26 (+/-233.97) (17.00-1843.00) µg/L222
DispersionL:17.00, M:215.26, H:1843.00 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN) 1.74 times higher than the average normal concentration.

Pathological associations
23.07.1996NephrologicSerum hyaluronan concentrations predi...Serum hyaluronan is a strong independent predictor of long-term survival in chronic renal failure.
07.03.2001otherHigh glucose stimulates hyaluronan pr...Results suggest that Hyaluronan may play a role in the pathogenesis of interstitial fibrosis in diabetic kidney disease.

10Only maximum range available, or detection limit used as maximum range.
16Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.